N. Akamatsu, Y. Sugawara, S. Tamura, J. Kaneko, Y. Matsui, J. Togashi, M. Makuuchi

背景：在成人-成人活体肝移植（LDLT）中，我们很少讨论捐赠者的年龄是否会对受体的术后疗效产生消极影响。本研究的目的是研究成人-成人活体肝移植中高龄捐赠者（50岁或50岁以上）对受体疗效的影响。

方法：我们将297名患者（299例LDLT）分为两组，年轻组（Y组，捐赠者年龄<50，n = 237）和老年组（O组，捐赠者年龄≥50，n = 62）。研究中我们回顾性评价了以上的LDLT数据。两组中捐赠者和受体的临床参数都相似。

结果：两组中捐赠者和受体的存活率以及术后并发症没有差异。O组受体的肝脏再生明显受损。两组中的移植肝肝功能（包括蛋白合成和胆汁淤积）均相似。

结论：尽管来自高龄捐赠者的肝脏在肝脏再生方面明显受损，但是移植肝肝功能与年轻组相比并无差异。因此，两组的临床疗效之间没有差异。

Impact of Live Donor Age (≥50) on Liver Transplantation
N. Akamatsu, Y. Sugawara, S. Tamura, J. Kaneko, Y. Matsui, J. Togashi, M. Makuuchi

Background: The question of whether donor age negatively impacts recipient outcome in adult-to-adult living donor liver transplantation (LDLT) is rarely discussed. The aim of this study was to evaluate the impact of older donor age (50 years or older) on recipient outcomes in adult-to-adult LDLT.

Methods: LDLT data were retrospectively evaluated from our 299 LDLT cases in 297 recipients, which were divided into 2 groups: a younger group (group Y, donor age <50, n = 237) and an older group (Group O, donor age ≥50, n = 62). Clinical parameters of both recipients and donors were comparable between groups.

Results: There was no difference between the groups in patient survival or postoperative complications of either donors or recipients. In recipients, graft regeneration was significantly impaired in Group O. Graft function, including protein synthesis and cholestasis, was comparable between the 2 groups.

Conclusion: Although the regeneration capacity of aged grafts was impaired, the function of grafts from older donors was comparable to that of those from younger donors. There was no difference in the clinical outcomes between the groups.

Volume 39, Issue 10, Pages 3189-3193 (December 2007)

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